Diabetes mellitus, or impaired glucose intolerance does not necessarily seem to play a role. Potential contributing factors for the development of neuropathic ulcers of the feet in patients with acromegalic gigantism and neuropathy might be leg and foot deformities, muscle weakness and poor quality footwear.
Neuropathies of the sural nerve in patients with acromegalic gigantism can lead to hypoesthesia and hypoalgesia of the lower legs and feet. These ulcers significantly impaired the daily activities of these individuals. Neuropathic foot ulcers leading to hospital admissions and surgical and medical interventions were reported in 6 patients with acromegalic gigantism. The combined final height and maximum weight of these giants were: 272 cm. The case histories of 6 famous patients with acromegalic gigantism and living in the twentieth century were analyzed. We present a historical overview on neuropathic ulcers in patients with acromegalic gigantism.
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